Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 20/20 | 0.55 |
| ▸ | PDE4A | P27815 | 10/20 | 0.55 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2979183 | 0.86 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL673206 | 0.86 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL4077540 | 0.80 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL20134704 | 0.79 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL2966972 | 0.78 | PDE4B (0.45) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL3550817 | 0.78 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL3554026 | 0.76 | PDE4A (0.50) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL14875109 | 0.76 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL3395541 | 0.74 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL3558282 | 0.74 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101389330-A | Methods for treating cutaneous lupus using aminoisoindoline compounds | CELGENE CORP (US) | 2009-03-18 | — | — | CN | disclosed |
| EP-1965793-A1 | METHODS FOR TREATING CUTANEOUS LUPUS USING AMINOISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079182-A1 | METHODS FOR TREATING CUTANEOUS LUPUS USING AMINOISOINDOLINE COMPOUNDS | CELGENE CORPORATION (US) | 2007-07-12 | — | — | WO | disclosed |