Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.51 |
| ▸ | TNNI3K | Q59H18 | 5/20 | 0.51 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.50 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | ABL2 | P42684 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | FADS1 | O60427 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 1/20 | 0.46 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.46 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4767230 | 0.99 | BRAF (0.50) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL7498074 | 0.86 | EGFR (0.57) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL4765640 | 0.86 | EGFR (0.57) | BRAFEGFRCSF1RERBB2AURKA | |
| SCHEMBL4764733 | 0.85 | EGFR (0.59) | EGFRCSF1RTNKSERBB2AURKA | |
| SCHEMBL4770048 | 0.85 | EGFR (0.60) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL27442803 | 0.84 | BRAF (0.62) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL2461054 | 0.84 | BRAF (0.64) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL7493506 | 0.83 | BRAF (0.52) | BRAFTNNI3KTTBK1TTBK2EGFR | |
| SCHEMBL7495114 | 0.83 | TTBK1 (0.56) | TTBK1TTBK2EGFRABL1ABL2 | |
| SCHEMBL7498606 | 0.83 | BRAF (0.66) | BRAFTNNI3KTTBK1TTBK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101560214-A | 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2009-10-21 | — | — | CN | claimed |
| EP-1416935-B1 | 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-03-12 | — | — | EP | claimed |
| CN-1538847-A | 4-amino-6-phenyl-pyrrolo [2, 3-d ] pyrimidine derivatives | ��˹��ŵ�� | 2004-10-20 | — | — | CN | claimed |
| CN-101560214-B | 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives | NOVARTIS AG | 2011-05-25 | — | — | CN | disclosed |
| CN-101560214-A | 4-amino-6-phenyl-pyrrolo[2, 3-d]pyrimidine derivatives | NOVARTIS AG (CH) | 2009-10-21 | — | — | CN | disclosed |
| CN-1538847-A | 4-amino-6-phenyl-pyrrolo [2, 3-d ] pyrimidine derivatives | ��˹��ŵ�� | 2004-10-20 | — | — | CN | disclosed |