Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.75 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.74 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767356 | 0.95 | EDNRA (0.80) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL4771926 | 0.91 | EDNRA (0.81) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL4764655 | 0.91 | EDNRA (0.85) | EDNRAAGTR1AGTR2 | |
| SCHEMBL5787220 | 0.90 | EDNRA (0.86) | EDNRAAGTR1AGTR2 | |
| SCHEMBL4774226 | 0.90 | EDNRA (0.84) | EDNRAAGTR1AGTR2ACHELTB4R2 | |
| SCHEMBL4766054 | 0.90 | EDNRA (0.83) | EDNRAAGTR1AGTR2 | |
| SCHEMBL4764284 | 0.89 | EDNRA (0.81) | EDNRAAGTR1AGTR2 | |
| SCHEMBL4770295 | 0.88 | EDNRA (0.83) | EDNRAAGTR1AGTR2LTB4R2 | |
| SCHEMBL6539697 | 0.88 | EDNRA (0.80) | EDNRAAGTR1AGTR2 | |
| SCHEMBL4772075 | 0.88 | EDNRA (0.80) | EDNRAAGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002837-A1 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-12-17 | — | — | EP | disclosed |
| EP-1741713-A2 | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists | Bristol-Myers Squibb Company (US) | 2007-01-10 | — | — | EP | disclosed |