Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARG | Q86W56 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769485 | 1.00 | PARG (0.37) | PARGMAPTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL4762693 | 0.95 | MAPT (0.36) | PARGMAPTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL4762695 | 0.95 | MAPT (0.36) | PARGMAPTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL4763160 | 0.92 | PARG (0.42) | PARGMAPTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL4763164 | 0.92 | PARG (0.42) | PARGMAPTPOLBSMN1; SMN2MEN1 | |
| SCHEMBL4763887 | 0.89 | MAPT (0.45) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4763895 | 0.89 | MAPT (0.45) | MAPTPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL4763875 | 0.87 | MEN1 (0.35) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4763878 | 0.87 | MEN1 (0.35) | MAPTSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4770647 | 0.84 | ADORA2A (0.33) | MAPTALDH1A1PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678181-B1 | A2B ADENOSINE RECEPTOR ANTAGONISTS | CV THERAPEUTICS INC (US) | 2008-12-31 | — | — | EP | disclosed |