Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 11/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.55 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27834457 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| Fumaric Acid SCHEMBL27729433 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| Fumaric Acid SCHEMBL27834458 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| SCHEMBL29985915 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| SCHEMBL254252 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| SCHEMBL39644 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| SCHEMBL39643 | 0.94 | MAPT (0.60) | HCAR2MAPTCACNA1BAPBA1APP | |
| SCHEMBL1906274 | 0.92 | MAPT (0.58) | HCAR2MAPTCACNA1BAPBA1APP | |
| SCHEMBL1906696 | 0.92 | MAPT (0.58) | HCAR2MAPTCACNA1BAPBA1APP | |
| Water SCHEMBL586051 | 0.92 | MAPT (0.58) | HCAR2MAPTCACNA1BAPBA1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948960-B1 | Nonionically derivatized starches and their use in non-aerosol, low voc hair fixative compositions | NAT STARCH CHEM INVEST (US) | 2008-12-31 | — | — | EP | claimed |
| EP-0948959-B1 | Nonionically derivatized starches and their use in low voc, polyacrylic acid-containing hair fixative compositions | NAT STARCH CHEM INVEST (US) | 2008-12-31 | — | — | EP | claimed |
| EP-0948958-B1 | Non-ionically derivatized starches and their use in aerosol hair fixative compositions | NAT STARCH CHEM INVEST (US) | 2006-06-21 | — | — | EP | claimed |
| CN-111417372-A | Alkali-swellable multifunctional rheology modifier | 诺力昂化学品国际有限公司 | 2020-07-14 | — | — | CN | disclosed |
| US-5196495-A | Hair spray; terpolymer of a vinyl ester, alkyl maleate half ester and a substituted acrylamide | ISP INVESTMENTS INC. (US) | 1993-03-23 | — | — | US | disclosed |
| WO-1992013014-A1 | HAIR FIXATIVE POLYMERS | ISP INVESTMENTS INC. (US) | 1992-08-06 | — | — | WO | disclosed |