Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 2/20 | 0.55 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 18/20 | 0.55 |
| ▸ | BRAF | P15056 | 10/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.53 |
| ▸ | TNNI3K | Q59H18 | 9/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766035 | 0.90 | KDR (0.64) | MAP3K7MAP4K2KDRBRAFMAPK14 | |
| SCHEMBL4766055 | 0.90 | MAP3K7 (0.69) | MAP3K7MAP4K2KDRBRAFMAPK14 | |
| SCHEMBL4929645 | 0.85 | KDR (0.65) | MAP3K7MAP4K2KDRBRAFMAPK14 | |
| SCHEMBL13528824 | 0.83 | SRC (0.60) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL4766143 | 0.81 | KDR (0.61) | MAP3K7MAP4K2KDRBRAFMAPK14 | |
| SCHEMBL4763219 | 0.81 | KDR (0.69) | MAP3K7MAP4K2KDRBRAFMAPK14 | |
| SCHEMBL4935782 | 0.79 | KDR (0.58) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL4932639 | 0.79 | KDR (0.64) | MAP3K7MAP4K2KDRBRAFMAPK14 | |
| SCHEMBL4933188 | 0.79 | KDR (0.59) | KDRBRAFMAPK14TNNI3K | |
| SCHEMBL3173197 | 0.79 | KDR (0.59) | MAP3K7MAP4K2KDRBRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511730-B1 | DIARYL UREA DERIVATIVES USEFUL FOR THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES | NOVARTIS AG (CH) | 2008-12-10 | — | — | EP | disclosed |