Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.64 |
| ▸ | YES1 | P07947 | 1/20 | 0.64 |
| ▸ | RET | P07949 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764290 | 0.91 | EGFR (0.76) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL27585239 | 0.85 | EGFR (0.76) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL4764275 | 0.85 | EGFR (0.76) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL27603019 | 0.85 | EGFR (0.79) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL4764304 | 0.85 | EGFR (0.79) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL14066936 | 0.85 | EGFR (0.82) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL4766628 | 0.84 | EGFR (0.77) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL27603129 | 0.83 | EGFR (0.79) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL4900347 | 0.83 | EGFR (0.82) | EGFRCSF1RERBB2HDAC3HDAC4 | |
| SCHEMBL4768460 | 0.83 | EGFR (0.82) | EGFRCSF1RERBB2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416935-B1 | 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-03-12 | — | — | EP | claimed |