Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5925812 | 0.85 | KDM4E (0.41) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL5818365 | 0.85 | KDM4E (0.51) | GAAKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL4771954 | 0.81 | GAA (0.43) | GAAKDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL29511129 | 0.79 | KDM4E (0.45) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL5820160 | 0.77 | KDM4E (0.52) | GAAKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL4770251 | 0.77 | CFTR (0.47) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL149267 | 0.74 | GAA (0.44) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL7395768 | 0.74 | GAA (0.54) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL26732929 | 0.73 | GAA (0.54) | GAAKDM4EALDH1A1HPGDPOLB | |
| SCHEMBL21857652 | 0.73 | GAA (0.42) | GAAKDM4EALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393851-B2 | Azaindole derivatives as inhibitors of p38 kinase | SCIOS, INC. (US) | 2008-07-01 | — | — | US | disclosed |
| EP-1560582-A4 | AZAINDOLE DERIVATIVES AS INHIBITORS OF p38 KINASE | SCIOS INC (US) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006112828-A1 | AZAINDOLE DERIVATIVES AS INHIBITORS OF P38 KINASE | SCIOS, INC. (US) | 2006-10-26 | — | — | WO | disclosed |
| US-20050288299-A1 | Azaindole derivatives as inhibitors of p38 kinase | SCIOS INC. | 2005-12-29 | — | — | US | disclosed |
| EP-1560582-A2 | AZAINDOLE DERIVATIVES AS INHIBITORS OF p38 KINASE | SCIOS INC. (US) | 2005-08-10 | — | — | EP | disclosed |
| WO-2004032874-A2 | AZAINDOLE DERIVATIVES AS INHIBITORS OF p38 KINASE | SCIOS INC. (US) | 2004-04-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288299-A1 | Azaindole derivatives as inhibitors of p38 kinase | MAPKAPK2, MAPK1, MAPK3 | GAA 4429/4885KDM4E 2446/4885ALDH1A1 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.