Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 7/20 | 0.59 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.35 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 3/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL477008 | 0.90 | CSNK1E (0.63) | CSNK1EPRKD1PRKD2EIF2AK4LATS1 | |
| SCHEMBL477012 | 0.86 | CSNK1E (0.58) | CSNK1EPRKD1PRKD2EIF2AK4LATS1 | |
| SCHEMBL17976948 | 0.86 | CSNK1E (0.76) | CSNK1EPRKD1PRKD2EIF2AK4 | |
| SCHEMBL477156 | 0.82 | CSNK1E (0.55) | CSNK1EPRKD1PRKD2ROCK2ROCK1 | |
| SCHEMBL477157 | 0.82 | CSNK1E (0.55) | CSNK1EPRKD1PRKD2ROCK2ROCK1 | |
| SCHEMBL1746568 | 0.80 | CSNK1E (0.77) | CSNK1ELATS1 | |
| SCHEMBL477166 | 0.80 | CSNK1E (0.50) | CSNK1EPRKD1EIF2AK4ROCK2ROCK1 | |
| SCHEMBL477167 | 0.80 | CSNK1E (0.50) | CSNK1EPRKD1EIF2AK4ROCK2ROCK1 | |
| SCHEMBL1395007 | 0.80 | CSNK1E (0.51) | CSNK1EEIF2AK4ROCK2ROCK1CDK4 | |
| SCHEMBL3114281 | 0.80 | CSNK1E (0.81) | CSNK1EPRKD1PRKD2EIF2AK4LATS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331546-B1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2012-02-01 | — | — | EP | disclosed |