Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.45 |
| ▸ | CNR1 | P21554 | 5/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL883824 | 0.85 | PTGDR2 (0.55) | PTGDR2FFAR1MRGPRX4KCNQ3KCNQ2 | |
| SCHEMBL12775547 | 0.84 | PTGDR2 (0.49) | PTGDR2FFAR1MRGPRX4KCNQ3KCNQ2 | |
| SCHEMBL585958 | 0.83 | PTGDR2 (0.48) | PTGDR2FFAR1MRGPRX4KCNQ3KCNQ2 | |
| SCHEMBL1651648 | 0.83 | PTGDR2 (0.39) | PTGDR2CNR1NR1I2CACNA1BSLC6A9 | |
| SCHEMBL585257 | 0.80 | PTGDR2 (0.46) | PTGDR2FFAR1MRGPRX4KCNQ3KCNQ2 | |
| SCHEMBL586021 | 0.79 | PTGDR2 (0.44) | PTGDR2SLC6A9FFAR1MRGPRX4S1PR2 | |
| SCHEMBL585990 | 0.78 | PTGDR2 (0.44) | PTGDR2FFAR1MRGPRX4KCNQ3KCNQ2 | |
| SCHEMBL585820 | 0.77 | KCNQ3 (0.45) | PTGDR2SLC6A9FFAR1MRGPRX4KCNQ3 | |
| SCHEMBL883843 | 0.77 | PTGDR2 (0.56) | PTGDR2FFAR1MRGPRX4 | |
| SCHEMBL4638046 | 0.76 | PTGDR2 (0.47) | PTGDR2SLC6A9FFAR1KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963259-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | AstraZeneca AB (SE) | 2008-09-03 | — | — | EP | claimed |
| WO-2007068894-A2 | SUBSTITUTED DIPHENYLETHERS, -AMINES, -SULFIDES AND -METHANES FOR THE TREATMENT OF RESPIRATORY DISEASE | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |