Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | CTSL | P07711 | 2/20 | 0.30 |
| ▸ | CTSS | P25774 | 2/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSK | P43235 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4766828 | 0.86 | NPC1 (0.32) | — | |
| SCHEMBL4765022 | 0.82 | PSEN1 (0.34) | — | |
| SCHEMBL7424005 | 0.81 | PSEN1 (0.35) | — | |
| SCHEMBL6206632 | 0.80 | CHEK1 (0.31) | — | |
| SCHEMBL4762955 | 0.79 | PSEN1 (0.32) | — | |
| SCHEMBL6206759 | 0.79 | PSEN1 (0.32) | — | |
| SCHEMBL6204977 | 0.79 | PSEN1 (0.32) | — | |
| SCHEMBL7425904 | 0.78 | PSEN1 (0.37) | CTSLCTSSCTSK | |
| SCHEMBL4761916 | 0.78 | PSEN1 (0.33) | CTSLCTSSCTSBCTSK | |
| SCHEMBL6203188 | 0.78 | PSEN1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |