SCHEMBL4770930

SCHEMBL4770930

CC(=O)N(Cc1cc(C(F)(F)F)cc(C(F)(F)F)c1)C1CCCN(OC(=O)OC(C)C)c2ccncc21

nearest known ligand 0.49

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CETP P11597 18/20 0.49
GPBAR1 Q8TDU6 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4772571 0.94 CETP (0.49) CETPGPBAR1
SCHEMBL3823317 0.89 CETP (0.51) CETP
SCHEMBL3823604 0.89 CETP (0.62) CETP
SCHEMBL4765555 0.88 CETP (0.53) CETP
SCHEMBL3827831 0.87 CETP (0.55) CETP
SCHEMBL3843347 0.85 CETP (0.55) CETP
SCHEMBL4768343 0.85 CETP (0.49) CETP
SCHEMBL4777167 0.84 CETP (0.50) CETP
SCHEMBL4770787 0.84 CETP (0.50) CETP
SCHEMBL4765951 0.84 CETP (0.49) CETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1732933-B1 COMPOUNDS FOR TREATING DYSLIPIDEMIA LILLY CO ELI (US) 2008-07-23 EP claimed