SCHEMBL4770978

SCHEMBL4770978

CC(CO)Oc1cc(Oc2cc(F)c(S(C)(=O)=O)cc2F)cc(C(=O)Nc2ccn(C)n2)c1

nearest known ligand 0.64

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GCK P35557 20/20 0.64
KCNH2 Q12809 6/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2905285 1.00 GCK (0.64) GCKKCNH2
SCHEMBL2906672 0.93 GCK (0.59) GCKKCNH2
SCHEMBL3592160 0.90 GCK (0.71) GCKKCNH2
SCHEMBL13255188 0.90 GCK (0.71) GCKKCNH2
SCHEMBL13209629 0.88 GCK (0.58) GCKKCNH2
SCHEMBL2654672 0.85 GCK (0.73) GCKKCNH2
SCHEMBL2659800 0.84 GCK (0.73) GCKKCNH2
SCHEMBL2662601 0.84 GCK (0.67) GCKKCNH2
SCHEMBL2654104 0.83 GCK (0.79) GCKKCNH2
SCHEMBL2654767 0.83 GCK (0.79) GCKKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1992623-A1 Heteroaryl benzamide derivative for use as GLK activator in the treatment of diabetes Astra Zeneca AB (SE) 2008-11-19 EP disclosed