Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495695 | 0.89 | CSNK1E (0.38) | CSNK1EDPP4RIPK3 | |
| SCHEMBL16496413 | 0.88 | CSNK1E (0.37) | CSNK1EDPP4RIPK3 | |
| SCHEMBL477024 | 0.82 | HRH3 (0.46) | CSNK1EDPP4RIPK3PDE2A | |
| SCHEMBL477166 | 0.74 | CSNK1E (0.50) | CSNK1ERIPK3 | |
| SCHEMBL477167 | 0.74 | CSNK1E (0.50) | CSNK1ERIPK3 | |
| SCHEMBL477028 | 0.73 | CSNK1E (0.52) | CSNK1EDPP4RIPK3 | |
| SCHEMBL477156 | 0.73 | CSNK1E (0.55) | CSNK1E | |
| SCHEMBL477157 | 0.73 | CSNK1E (0.55) | CSNK1E | |
| SCHEMBL477063 | 0.70 | HRH3 (0.52) | CSNK1EDPP4RIPK3 | |
| SCHEMBL477022 | 0.69 | HRH3 (0.48) | CSNK1EDPP4RIPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2331546-B1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2012-02-01 | — | — | EP | disclosed |
| EP-2331546-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | Sanofi-aventis (FR) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010018327-A1 | 2-ALKYL-6-CYCLOAMINO-3-(PYRIDIN-4-YL)IMIDAZO[1,2-IB]-PYRIDAZINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC APPLICATION THEREOF | SANOFI-AVENTIS (FR) | 2010-02-18 | — | — | WO | disclosed |