Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAL | P20701 | 10/20 | 0.63 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.45 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | TFEB | P19484 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4283957 | 0.89 | ITGAL (0.67) | ITGALITGB2ICAM1ARABCG2 | |
| SCHEMBL4283960 | 0.89 | ITGAL (0.67) | ITGALITGB2ICAM1ARABCG2 | |
| SCHEMBL4290311 | 0.84 | ITGAL (0.58) | ITGALITGB2ICAM1ARABCG2 | |
| SCHEMBL4290308 | 0.84 | ITGAL (0.58) | ITGALITGB2ICAM1ARABCG2 | |
| SCHEMBL13879663 | 0.84 | ITGAL (0.58) | ITGALITGB2ICAM1HTTLMNA | |
| SCHEMBL13879651 | 0.82 | ITGAL (0.57) | ITGALITGB2ICAM1HTTLMNA | |
| SCHEMBL13879648 | 0.82 | ITGAL (0.78) | ITGALITGB2ICAM1HPGDKDM4E | |
| SCHEMBL2128820 | 0.81 | ITGAL (0.54) | ITGALITGB2ICAM1ARHTT | |
| SCHEMBL13879660 | 0.81 | ITGAL (0.74) | ITGALITGB2ICAM1HPGDKDM4E | |
| SCHEMBL13879658 | 0.81 | ITGAL (0.79) | ITGALITGB2ICAM1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943228-A2 | INHIBITORS OF VIRAL REPLICATION | Intermune, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007047146-A2 | INHIBITORS OF VIRAL REPLICATION | INTERMUNE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |