Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.52 |
| ▸ | BRAF | P15056 | 5/20 | 0.41 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46796 | 0.94 | SLC34A2 (0.52) | SLC34A2BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL39793 | 0.94 | SLC34A2 (0.52) | SLC34A2BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL46797 | 0.94 | SLC34A2 (0.52) | SLC34A2BRAFRAF1TEKROCK2 | |
| SCHEMBL46782 | 0.93 | SLC34A2 (0.51) | SLC34A2BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL19596279 | 0.92 | SLC34A2 (0.49) | SLC34A2BRAFRAF1TEKROCK2 | |
| SCHEMBL19579944 | 0.92 | SLC34A2 (0.52) | SLC34A2BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL19580033 | 0.91 | SLC34A2 (0.51) | SLC34A2BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL19579980 | 0.90 | SLC34A2 (0.52) | SLC34A2BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL6002472 | 0.90 | SLC34A2 (0.55) | SLC34A2BRAFRAF1TEKROCK2 | |
| SCHEMBL46788 | 0.89 | SLC34A2 (0.52) | SLC34A2BRAFRAF1TEKROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590656-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-2591354-B1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX INC (US) | 2016-09-07 | — | — | EP | disclosed |
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |