Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 6/20 | 1.00 |
| ▸ | BUB1 | O43683 | 7/20 | 0.60 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.50 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.50 |
| ▸ | CLK2 | P49760 | 2/20 | 0.50 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.50 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4772983 | 0.99 | CDC7 (0.97) | CDC7BUB1PKN1PKN2MAPKAPK2 | |
| SCHEMBL6110534 | 0.87 | CDC7 (0.76) | CDC7BUB1MAPKAPK2PARP10PARP11 | |
| SCHEMBL6110112 | 0.84 | CDC7 (0.72) | CDC7BUB1MAPKAPK2PIM1PIM2 | |
| SCHEMBL6099517 | 0.84 | CDC7 (0.72) | CDC7BUB1MAPKAPK2PARP10PARP11 | |
| SCHEMBL6109539 | 0.83 | CDC7 (0.71) | CDC7BUB1MAPKAPK2PARP10PARP11 | |
| SCHEMBL17847562 | 0.82 | CDC7 (0.70) | CDC7BUB1PKN1PKN2MAPKAPK2 | |
| SCHEMBL6109948 | 0.82 | CDC7 (0.69) | CDC7BUB1PKN1PKN2MAPKAPK2 | |
| SCHEMBL6110458 | 0.81 | CDC7 (0.67) | CDC7BUB1PKN1PKN2MAPKAPK2 | |
| SCHEMBL30444069 | 0.80 | BUB1 (0.67) | CDC7BUB1PKN1PKN2MAPKAPK2 | |
| SCHEMBL7690471 | 0.79 | CDC7 (0.66) | CDC7BUB1PKN1PKN2CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | claimed |