Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4287812 | 0.88 | KDR (0.45) | KDRFGFR1 | |
| SCHEMBL4278293 | 0.85 | KDR (0.55) | KDRFGFR1 | |
| SCHEMBL4279915 | 0.84 | KDR (0.46) | KDRFGFR1 | |
| SCHEMBL4284980 | 0.83 | KDR (0.56) | KDRFGFR1 | |
| SCHEMBL4285980 | 0.82 | KDR (0.50) | KDRFGFR1EGFR | |
| SCHEMBL4282048 | 0.81 | KDR (0.49) | KDRFGFR1EGFR | |
| SCHEMBL4280702 | 0.79 | KDR (0.43) | KDRFGFR1EGFR | |
| SCHEMBL4283735 | 0.78 | KDR (0.49) | KDRFGFR1 | |
| SCHEMBL4286017 | 0.75 | KDR (0.51) | KDRFGFR1EGFR | |
| SCHEMBL4292556 | 0.74 | KDR (0.40) | KDRFGFR1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |