Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.34 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10615348 | 0.89 | TSHR (0.47) | TSHRHPGDCYP3A4CA2CA1 | |
| SCHEMBL4163827 | 0.89 | TSHR (0.47) | TSHRHPGDCYP3A4CA2CA1 | |
| SCHEMBL3966436 | 0.89 | TSHR (0.42) | TSHRHPGDTHRBALDH1A1CYP3A4 | |
| SCHEMBL27449093 | 0.83 | TSHR (0.41) | TSHRHPGDCA2CA1CTSK | |
| SCHEMBL27545815 | 0.83 | TSHR (0.41) | TSHRHPGDALDH1A1CA2CA1 | |
| SCHEMBL4163832 | 0.83 | HCAR2 (0.49) | TSHRHPGDCA2ATMMAPK1 | |
| SCHEMBL10615354 | 0.83 | HCAR2 (0.49) | TSHRHPGDCA2ATMMAPK1 | |
| SCHEMBL4163836 | 0.83 | HCAR2 (0.49) | TSHRHPGDCA2ATMMAPK1 | |
| SCHEMBL1632839 | 0.81 | TSHR (0.44) | TSHRHPGDALDH1A1CYP3A4CA2 | |
| SCHEMBL9578994 | 0.81 | TSHR (0.54) | TSHRHPGDTHRBALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638539-B1 | PHARMACEUTICAL COMPOSITIONS COMPRISING PH-SENSITIVE BLOCK COPOLYMERS AND A HYDROPHOBIC DRUG | UNIV MONTREAL (CA) | 2008-12-31 | — | — | EP | claimed |