Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 7/20 | 0.39 |
| ▸ | ACHE | P22303 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.37 |
| ▸ | CHRNE | Q04844 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5135688 | 0.90 | C5AR1 (0.45) | C5AR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4769336 | 0.90 | C5AR1 (0.43) | C5AR1BCHEALDH1A1KDM4ELMNA | |
| SCHEMBL5134844 | 0.89 | C5AR1 (0.44) | C5AR1ALDH1A1KDM4ETSHRGNRHR | |
| SCHEMBL5074353 | 0.89 | C5AR1 (0.44) | C5AR1BCHEACHEALDH1A1KDM4E | |
| SCHEMBL5135193 | 0.88 | BCHE (0.43) | C5AR1BCHEACHETACR1CASR | |
| SCHEMBL5069962 | 0.88 | BCHE (0.45) | C5AR1BCHEACHETACR1CASR | |
| SCHEMBL5137131 | 0.86 | C5AR1 (0.41) | C5AR1ALDH1A1KDM4ETSHRTP53 | |
| SCHEMBL5134673 | 0.85 | C5AR1 (0.43) | C5AR1BCHEACHEALDH1A1KDM4E | |
| SCHEMBL5135095 | 0.85 | BCHE (0.47) | C5AR1BCHEACHEMAOBTP53 | |
| SCHEMBL5137586 | 0.85 | C5AR1 (0.40) | C5AR1ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1322309-B1 | HIGH AFFINITY SMALL MOLECULE C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2008-08-13 | — | — | EP | claimed |