Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 11/20 | 0.71 |
| ▸ | WEE1 | P30291 | 4/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | SRC | P12931 | 2/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CCND1 | P24385 | 2/20 | 0.50 |
| ▸ | CCND2 | P30279 | 2/20 | 0.50 |
| ▸ | CCND3 | P30281 | 2/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CDK7 | P50613 | 1/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.50 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527194 | 0.93 | CSF1R (0.82) | CSF1RWEE1EGFRBTKCDK4 | |
| SCHEMBL3529808 | 0.92 | CSF1R (0.69) | CSF1RWEE1EGFRBTKCDK4 | |
| SCHEMBL4767401 | 0.90 | CSF1R (0.86) | CSF1RWEE1EGFRCDK4AURKA | |
| SCHEMBL3528897 | 0.90 | CSF1R (0.66) | CSF1RWEE1EGFRBTKCDK4 | |
| SCHEMBL3527206 | 0.90 | CSF1R (0.65) | CSF1RWEE1EGFRBTKCDK4 | |
| SCHEMBL4791572 | 0.89 | CSF1R (0.86) | CSF1RWEE1EGFRCDK4AURKA | |
| SCHEMBL3530467 | 0.83 | CSF1R (1.00) | CSF1RWEE1CDK4AURKASRC | |
| SCHEMBL3530165 | 0.82 | CSF1R (0.83) | CSF1RWEE1CDK4AURKASRC | |
| SCHEMBL4884345 | 0.82 | CSF1R (0.81) | CSF1RWEE1CDK4AURKASRC | |
| SCHEMBL3527526 | 0.82 | CSF1R (1.00) | CSF1RWEE1CDK4AURKASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |