Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | DRD1 | P21728 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | TPO | P07202 | 1/20 | 0.31 |
| ▸ | EPX | P11678 | 1/20 | 0.31 |
| ▸ | LPO | P22079 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | KMO | O15229 | 1/20 | 0.30 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4292419 | 0.87 | EGFR (0.36) | EGFRKDRRETALDH1A1CSF1R | |
| SCHEMBL4284118 | 0.78 | RET (0.38) | KDRRETALDH1A1KMOCSF1R | |
| SCHEMBL4281127 | 0.77 | EGFR (0.40) | EGFRKDRRETDRD1TSHR | |
| SCHEMBL4278148 | 0.74 | RET (0.36) | KDRRETKMOCSF1RKIT | |
| SCHEMBL14414778 | 0.71 | RET (0.48) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL4290591 | 0.70 | DYRK1A (0.45) | EGFRKDRDRD1 | |
| SCHEMBL4282197 | 0.70 | RET (0.36) | EGFRKDRRETCSF1RKIT | |
| SCHEMBL4285394 | 0.69 | KDR (0.33) | EGFRKDRRET | |
| SCHEMBL2451070 | 0.68 | RET (0.48) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL4282301 | 0.68 | EGFR (0.41) | EGFRKDRRETDRD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904498-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007004749-A1 | FUSED HETEROCYCLIC DERIVATIVES AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-01-11 | — | — | WO | disclosed |