Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 18/20 | 0.58 |
| ▸ | PLK3 | Q9H4B4 | 9/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL577969 | 0.85 | PLK1 (0.59) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL4345776 | 0.80 | PLK1 (0.63) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL4182116 | 0.78 | PLK1 (0.62) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL8929589 | 0.77 | PLK1 (0.50) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL577810 | 0.76 | PLK1 (0.49) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL1372501 | 0.75 | PLK1 (0.59) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL2524649 | 0.75 | PLK1 (0.71) | PLK1 | |
| SCHEMBL1371628 | 0.75 | PLK1 (0.59) | PLK1PLK3CDK2IKBKECYP2C9 | |
| SCHEMBL15826856 | 0.74 | PLK1 (0.73) | PLK1 | |
| SCHEMBL2522248 | 0.74 | PLK1 (0.75) | PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2007757-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmceuticals Incorporated (US) | 2008-12-31 | — | — | EP | disclosed |
| WO-2007120760-A2 | THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-25 | — | — | WO | disclosed |