Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 4/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.48 |
| ▸ | USP2 | O75604 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359186 | 0.85 | PDE5A (0.35) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4353426 | 0.77 | HTT (0.43) | CYP1A2CYP3A4CYP2D6CYP2C19CLK4 | |
| SCHEMBL4357479 | 0.76 | IRAK4 (0.75) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4353446 | 0.75 | IRAK4 (0.77) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4358072 | 0.71 | CD38 (0.64) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4351313 | 0.71 | MAP4K4 (0.74) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4355129 | 0.71 | DYRK1A (0.33) | CYP1A2DYRK1A | |
| SCHEMBL21318842 | 0.70 | IRAK4 (0.73) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL17665803 | 0.70 | CD38 (0.63) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL4355227 | 0.70 | CYP1A2 (0.67) | CD38CYP1A2CYP3A4CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009078-A2 | 4,6-DL- AND 2,4,6-TRISUBSTITUTED QUINAZOLINE DERIVATIVES USEFUL FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |