Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 2/20 | 0.42 |
| ▸ | SLC16A1 | P53985 | 2/20 | 0.42 |
| ▸ | MCTS1 | Q9ULC4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3206403 | 0.81 | PPARG (0.74) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3207494 | 0.80 | PPARG (0.53) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4774031 | 0.76 | PPARG (0.49) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3208410 | 0.76 | PPARG (0.61) | PPARG | |
| SCHEMBL5108762 | 0.75 | PPARG (0.57) | PPARGNPC1 | |
| SCHEMBL3204985 | 0.73 | PPARG (0.64) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3210282 | 0.73 | NPC1 (0.51) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3204975 | 0.73 | PPARG (0.64) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3216020 | 0.71 | PPARG (0.54) | PPARGNPC1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5107833 | 0.70 | PPARG (0.56) | PPARGSLC16A3SLC16A1MCTS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912645-A2 | THERAPEUTIC AGENT FOR DIABETES | Takeda Pharmaceutical Company Limited (JP) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007018314-A2 | THERAPEUTIC AGENT FOR DIABETES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-02-15 | — | — | WO | disclosed |