Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 5/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.45 |
| ▸ | EGFR | P00533 | 5/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770740 | 0.79 | EGFR (0.57) | CYP1A2CLK4EGFRCSF1R | |
| SCHEMBL4763918 | 0.78 | EGFR (0.56) | CYP1A2CLK4EGFRCSF1R | |
| SCHEMBL7494319 | 0.75 | EGFR (0.62) | CYP1A2CLK4EGFRAURKARPS6KB1 | |
| SCHEMBL4769581 | 0.73 | EGFR (0.63) | CYP1A2CLK4EGFRCSF1R | |
| SCHEMBL4766798 | 0.73 | EGFR (0.59) | CYP1A2CLK4EGFRAURKARPS6KB1 | |
| SCHEMBL4767245 | 0.73 | CSF1R (0.66) | CYP1A2CLK4EGFRCSF1R | |
| SCHEMBL39893 | 0.72 | CYP1A2 (0.58) | CYP1A2CLK4CYP3A4TSHRALDH1A1 | |
| SCHEMBL4766838 | 0.72 | CSF1R (0.60) | CYP1A2CLK4EGFRCSF1RCYP3A4 | |
| SCHEMBL4766521 | 0.70 | CSF1R (0.58) | CYP1A2CLK4EGFRCSF1RCYP3A4 | |
| SCHEMBL14075269 | 0.68 | EGFR (0.78) | EGFRCSF1RALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1416935-B1 | 4-AMINO-6-PHENYL-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-03-12 | — | — | EP | claimed |