SCHEMBL4774218

SCHEMBL4774218

CC(C)(C)OC(=O)N1CCC2(CCCC2)C(=O)C1

nearest known ligand 0.43

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
USP30 Q70CQ3 1/20 0.43
USP2 O75604 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ESR2 Q92731 1/20 0.42
NR1H2 P55055 3/20 0.41
MAPK1 P28482 1/20 0.41
HPGD P15428 1/20 0.40
HRH3 Q9Y5N1 4/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP11B2 P19099 1/20 0.39
ADORA1 P30542 1/20 0.39
EPHX1 P07099 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18838278 0.97 USP30 (0.43) USP30USP2SMN1; SMN2ESR2NR1H2
SCHEMBL736466 0.94 ESR2 (0.47) USP30USP2SMN1; SMN2ESR2NR1H2
SCHEMBL16914278 0.88 USP2 (0.44) USP30USP2SMN1; SMN2HPGDHRH3
SCHEMBL24088990 0.87 HPGD (0.43) USP30USP2SMN1; SMN2HPGDHRH3
SCHEMBL22958850 0.87 HPGD (0.43) USP30USP2SMN1; SMN2HPGDHRH3
SCHEMBL4774216 0.86 USP2 (0.45) USP30USP2SMN1; SMN2HPGDHRH3
SCHEMBL17107652 0.86 NR1H2 (0.46) USP30USP2SMN1; SMN2ESR2NR1H2
SCHEMBL15552077 0.85 MAPK1 (0.41) USP30USP2SMN1; SMN2ESR2NR1H2
SCHEMBL3658167 0.85 MAPK1 (0.42) USP30USP2SMN1; SMN2ESR2NR1H2
SCHEMBL16914261 0.85 USP30 (0.44) USP30USP2SMN1; SMN2ESR2NR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3853233-A1 TRI-SUBSTITUTED HETEROARYL DERIVATIVES AS SRC HOMOLOGY-2 PHOSPHATASE INHIBITORS Nikang Therapeutics, Inc. (US) 2021-07-28 EP disclosed
EP-3645533-A1 TDO2 AND IDO1 INHIBITORS Genentech, Inc. (US) 2020-05-06 EP disclosed
WO-2020061101-A1 TRI-SUBSTITUTED HETEROARYL DERIVATIVES AS SRC HOMOLOGY-2 PHOSPHATASE INHIBITORS NIKANG THERAPEUTICS, INC. (US) 2020-03-26 WO disclosed
WO-2019005559-A1 TDO2 AND IDO1 INHIBITORS GENENTECH, INC. (US) 2019-01-03 WO disclosed
EP-3340988-A1 ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES Afasci, Inc. (US) 2018-07-04 EP disclosed
WO-2017083867-A1 ION CHANNEL INHIBITORY COMPOUNDS, PHARMACEUTICAL FORMULATIONS AND USES AFASCI, INC. (US) 2017-05-18 WO disclosed
EP-3094628-A1 N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 Novartis AG (CH) 2016-11-23 EP disclosed
WO-2015107495-A1 N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2 NOVARTIS AG (CH) 2015-07-23 WO disclosed
EP-1907372-A1 SUBSTITUTED CYCLOHEXYL DERIVATIVES AS NK-3 RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LTD. (GB) 2008-04-09 EP disclosed
WO-2007003965-A1 SUBSTITUTED CYCLOHEXYL DERIVATIVES AS NK-3 RECEPTOR ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 2007-01-11 WO disclosed