Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | NAAA | Q02083 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31442690 | 0.80 | NOTUM (0.51) | NOTUMUCHL1USP30FAAHNAAA | |
| SCHEMBL19279722 | 0.80 | NOTUM (0.51) | NOTUMUCHL1USP30FAAHNAAA | |
| SCHEMBL306243 | 0.80 | NOTUM (0.46) | NOTUMUCHL1USP30POLBEGFR | |
| SCHEMBL29753309 | 0.80 | NOTUM (0.46) | NOTUMUCHL1USP30POLBEGFR | |
| SCHEMBL4781137 | 0.78 | NOTUM (0.49) | NOTUMUCHL1USP30FAAHNAAA | |
| SCHEMBL30609086 | 0.76 | NOTUM (0.40) | NOTUMKDM4EL3MBTL1ADRB1 | |
| SCHEMBL13113610 | 0.76 | NOTUM (0.40) | NOTUMKDM4EL3MBTL1ADRB1 | |
| SCHEMBL20872567 | 0.75 | NOTUM (0.50) | NOTUMUCHL1USP30FAAHNAAA | |
| SCHEMBL6648039 | 0.72 | NOTUM (0.73) | NOTUMPOLBPDK1 | |
| SCHEMBL14158701 | 0.72 | NOTUM (0.43) | NOTUMKDM4EUCHL1USP30POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008008431-A2 | HETEROARYL SULFONAMIDES AND CCR2/CCR9 | CHEMOCENTRYX, INC. (US) | 2008-01-17 | — | — | WO | disclosed |