Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Moxifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.98 |
| ▸ | HPGD | P15428 | 4/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.98 |
| ▸ | MEN1 | O00255 | 1/20 | 0.98 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | CLK2 | P49760 | 1/20 | 0.71 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Moxifloxacin SCHEMBL1883937 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL15472879 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL29414621 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL29356466 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL24007 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL12015472 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL28408968 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL12156451 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL21783209 | 1.00 | KDM4E (0.98) | KDM4EALDH1A1HPGDHSD17B10MEN1 | |
| Moxifloxacin SCHEMBL2293939 | 0.99 | KDM4E (0.97) | KDM4EALDH1A1HPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018141063-A1 | BICARBONATE AS A POTENTIATOR FOR ANTIMICROBIAL AGENTS | MCMASTER UNIVERSITY (CA) | 2018-08-09 | — | — | WO | disclosed |
| EP-1992626-A1 | Process for the preparation of moxifloxacin hydrochloride | Sandoz AG (CH) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007093557-A1 | SULFONAMIDE DERIVATIVES FOR THE TREATMENT OF BACTERIAL INFECTIONS | LABORATOIRES SERONO S.A. (CH) | 2007-08-23 | — | — | WO | disclosed |