Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 6/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4097023 | 0.87 | ADORA2A (0.44) | MAPTMAPK1ADORA2AHSP90AB1DHFR | |
| SCHEMBL4107761 | 0.82 | HSP90AB1 (0.44) | MAPTKDM4EADORA2AHSP90AB1DHFR | |
| SCHEMBL4106705 | 0.82 | HSP90AB1 (0.44) | MAPTKDM4EADORA2AHSP90AB1DHFR | |
| SCHEMBL4106568 | 0.81 | ADORA2A (0.57) | MAPTMAPK1ADORA2AHSP90AB1DHFR | |
| SCHEMBL4102481 | 0.81 | HSP90AB1 (0.40) | MAPTADORA2AHSP90AB1DHFR | |
| SCHEMBL4109781 | 0.78 | ADORA2A (0.42) | MAPTADORA2AHSP90AB1DHFRNUDT1 | |
| SCHEMBL4108093 | 0.77 | HSP90AB1 (0.45) | MAPTMAPK1ADORA2AHSP90AB1DHFR | |
| SCHEMBL4112502 | 0.75 | HSP90AB1 (0.43) | MAPTADORA2AHSP90AB1DHFR | |
| SCHEMBL4102985 | 0.75 | HSP90AB1 (0.58) | MAPTKDM4EMAPK1ADORA2AHSP90AB1 | |
| SCHEMBL4103265 | 0.74 | HSP90AB1 (0.47) | ADORA2AHSP90AB1DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008009076-A2 | SUBSTITUTED PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VIRAL INFECTIONS | GILEAD SCIENCES, INC. (US) | 2008-01-24 | — | — | WO | disclosed |