Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 14/20 | 0.52 |
| ▸ | RAB9A | P51151 | 14/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | CASP3 | P42574 | 5/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4770312 | 0.94 | MAOB (0.49) | NPC1RAB9ASMN1; SMN2MAPTPKM | |
| SCHEMBL4770878 | 0.93 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTPKM | |
| Trifluoroacetic Acid SCHEMBL4768140 | 0.88 | SLC2A1 (0.48) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL4768701 | 0.88 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2MAPTPKM | |
| Trifluoroacetic Acid SCHEMBL4774281 | 0.85 | SLC2A1 (0.58) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4767916 | 0.83 | TMPRSS2 (0.55) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL4771412 | 0.82 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 | |
| SCHEMBL4770319 | 0.82 | HRH3 (0.41) | NPC1RAB9ASMN1; SMN2MAPTPKM | |
| Trifluoroacetic Acid SCHEMBL4775559 | 0.82 | SLC2A1 (0.47) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4765505 | 0.82 | SLC2A1 (0.50) | NPC1RAB9ASMN1; SMN2MAPTNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | claimed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | claimed |
| EP-1713778-B1 | BENZAZEPINE DERIVATIVES AS HISTAMINE H3 ANTAGONISTS | GLAXO GROUP LTD (GB) | 2008-01-16 | — | — | EP | disclosed |
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | GLAXO GROUP LIMITED (GB) | 2007-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060566-A1 | Benzazepine derivatives as histamine h3 antagonists | HRH3, HRH4, HRH1 | NPC1 2009/4885RAB9A 2307/4885SMN1; SMN2 2487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.