Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.73 |
| ▸ | AXL | P30530 | 11/20 | 0.73 |
| ▸ | INSR | P06213 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233948 | 0.87 | AXL (0.77) | BACE1AXLINSR | |
| SCHEMBL29928943 | 0.84 | BACE1 (1.00) | BACE1AXLINSR | |
| SCHEMBL4237164 | 0.84 | BACE1 (1.00) | BACE1AXLINSR | |
| SCHEMBL29928365 | 0.83 | BACE1 (0.75) | BACE1AXLINSR | |
| SCHEMBL1167563 | 0.83 | BACE1 (0.60) | BACE1AXLINSR | |
| SCHEMBL1167837 | 0.82 | BACE1 (0.59) | BACE1AXLINSR | |
| SCHEMBL4991637 | 0.82 | BACE1 (0.73) | BACE1AXLINSR | |
| SCHEMBL29929832 | 0.82 | BACE1 (0.73) | BACE1AXLINSR | |
| SCHEMBL4249916 | 0.82 | AXL (0.80) | BACE1AXL | |
| SCHEMBL1167941 | 0.82 | BACE1 (0.58) | BACE1AXLINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1922310-A2 | TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2008-05-21 | — | — | EP | claimed |
| WO-2007030680-A2 | TRIAZOLE DERIVATIVES USEFUL AS AXL INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2007-03-15 | — | — | WO | claimed |