Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Olanzapine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 7/20 | 1.00 |
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 1.00 |
| ▸ | HTR2C known ✓ | P28335 | 5/20 | 1.00 |
| ▸ | DRD4 known ✓ | P21917 | 4/20 | 1.00 |
| ▸ | DRD3 known ✓ | P35462 | 3/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 10/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 5/20 | 1.00 |
| ▸ | CHRM4 | P08173 | 5/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 5/20 | 1.00 |
| ▸ | CHRM3 | P20309 | 5/20 | 1.00 |
| ▸ | DRD1 | P21728 | 5/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 5/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 5/20 | 1.00 |
| ▸ | HRH1 | P35367 | 5/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 5/20 | 1.00 |
| ▸ | HTR2B | P41595 | 5/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 4/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 4/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olanzapine SCHEMBL29358280 | 1.00 | CHRM1 (1.00) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL28763 | 1.00 | CHRM1 (1.00) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL2222724 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL1376031 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL29278843 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL6461808 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL1375329 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL1562676 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL5091769 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 | |
| Olanzapine SCHEMBL29279662 | 0.99 | CHRM1 (0.98) | CHRM1DRD2CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102292094-A | Sorbic and benzoic acid and derivatives thereof enhance the activity of a neuropharmaceutical | — | 2011-12-21 | — | — | CN | claimed |
| CN-104136009-A | Rapidly disintegrating form of a drug and preparation method thereof | QUANTUM HI TECH BEIJING RES INST | 2014-11-05 | — | — | CN | disclosed |
| EP-1758600-A4 | METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER | MOOD MAN SCIENCES LLC (US) | 2008-03-05 | — | — | EP | disclosed |
| EP-1890700-A2 | METHODS AND COMPOSITIONS FOR MANAGING PSYCHOTIC DISORDERS | Orexigen Therapeutics, Inc. (US) | 2008-02-27 | — | — | EP | disclosed |
| EP-1758600-A1 | METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER | Mood Management Sciences, LLC (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006130522-A2 | METHODS AND COMPOSITIONS FOR MANAGING PSYCHOTIC DISORDERS | OREXIGEN THERAPEUTICS, INC. (US) | 2006-12-07 | — | — | WO | disclosed |
| EP-1720885-A1 | A PROCESS FOR MAKING OLANZAPINE IN A POLYMORPH FORM I | Synthon B.V. (NL) | 2006-11-15 | — | — | EP | disclosed |
| EP-1716154-A1 | PROCESS FOR THE PREPARATION OF OLANZAPINE FORM 1 USEFUL AS ANTIPSYCHOTIC DRUG | Neuland Laboratories Ltd (IN) | 2006-11-02 | — | — | EP | disclosed |
| WO-2006030300-A2 | PROCESSES FOR THE PREPARATION OF OLANZAPINE | RANBAXY LABORATORIES LIMITED (IN) | 2006-03-23 | — | — | WO | disclosed |
| WO-2005120523-A1 | METHODS AND COMPOSITIONS FOR TREATING MOOD DISORDER | MOOD MANAGEMENT SCIENCES, LLC (US) | 2005-12-22 | — | — | WO | disclosed |
| WO-2005080401-A1 | PROCESS FOR THE PREPARATION OF OLANZAPINE FORM 1 USEFUL AS ANTIPSYCHOTIC DRUG | NEULAND LABORATORIES LIMITED (IN) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005070937-A1 | A PROCESS FOR MAKING OLANZAPINE IN A POLYMORPH FORM I | SYNTHON B.V. (NL) | 2005-08-04 | — | — | WO | disclosed |