Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.34 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775060 | 0.88 | GAA (0.39) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4777347 | 0.83 | NR1H4 (0.39) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4771365 | 0.83 | GAA (0.37) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4777644 | 0.81 | GAA (0.45) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4777314 | 0.81 | GAA (0.38) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4776710 | 0.81 | GAA (0.43) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL5571819 | 0.80 | SLC6A4 (0.42) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4777561 | 0.80 | GAA (0.36) | GAAALDH1A1RECQLMAPTLMNA | |
| SCHEMBL4773507 | 0.80 | GAA (0.42) | GAAALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL4771202 | 0.79 | GAA (0.38) | GAAALDH1A1RECQLMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1942888-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007056078-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2007-05-18 | — | — | WO | disclosed |