SCHEMBL4777467

SCHEMBL4777467

CS(=O)(=O)N(Cc1cccc(Cl)c1Cl)c1ccc(CNC(=O)c2cccnc2)cc1

nearest known ligand 0.71

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.71
LMNA P02545 3/20 0.58
SMN1; SMN2 Q16637 1/20 0.58
TSHR P16473 1/20 0.54
MEN1 O00255 1/20 0.52
KMT2A Q03164 1/20 0.52
NAMPT P43490 8/20 0.51
ALDH1A1 P00352 1/20 0.49
NPC1 O15118 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4777502 0.85 GAA (0.62) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4776528 0.85 GAA (0.62) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4770931 0.85 GAA (0.62) GAALMNASMN1; SMN2TSHRKMT2A
SCHEMBL4775207 0.84 GAA (0.69) GAALMNASMN1; SMN2TSHRMEN1
SCHEMBL4767980 0.84 GAA (0.61) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4770895 0.84 GAA (0.71) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4773553 0.83 GAA (0.60) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4768019 0.83 GAA (1.00) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4777650 0.83 GAA (0.60) GAALMNASMN1; SMN2MEN1KMT2A
SCHEMBL4776481 0.83 GAA (0.60) GAALMNASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008018639-A2 GLYCINE TRANSPORTER INHIBITOR TAISHO PHARMACEUTICAL CO., LTD. (JP) 2008-02-14 WO disclosed