Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 19/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 10/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3637492 | 0.76 | PLK1 (0.74) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL4146430 | 0.74 | PLK1 (0.50) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL6241399 | 0.73 | PLK1 (0.55) | PLK1PLK3 | |
| SCHEMBL2986893 | 0.72 | PLK1 (0.73) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL2982011 | 0.72 | PLK1 (0.51) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL2990382 | 0.71 | PLK1 (0.72) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL4846733 | 0.71 | PLK1 (0.72) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL3574663 | 0.71 | PLK1 (0.72) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL4777503 | 0.71 | PLK1 (0.49) | PLK1PLK3CYP3A4CYP2C9 | |
| SCHEMBL4631593 | 0.71 | PLK1 (0.87) | PLK1PLK3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924572-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SmithKline Beecham Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007030366-A1 | REGIOSELECTIVE PROCESS FOR PREPARING BENZIMIDAZOLE THIOPHENES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |