Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.40 |
| ▸ | ACACA | Q13085 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4668265 | 1.00 | HRH3 (0.42) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| SCHEMBL4668344 | 1.00 | HRH3 (0.42) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| SCHEMBL4668242 | 0.97 | HRH3 (0.41) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| SCHEMBL4666773 | 0.97 | HRH3 (0.41) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| SCHEMBL4666695 | 0.97 | HRH3 (0.41) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| Hydrochloric Acid SCHEMBL4668308 | 0.96 | HRH3 (0.40) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| Hydrochloric Acid SCHEMBL4666655 | 0.96 | HRH3 (0.40) | HRH3ALDH1A1GPR119IKBKETBK1 | |
| SCHEMBL4667354 | 0.89 | HRH3 (0.44) | HRH3ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4667218 | 0.88 | HRH3 (0.44) | HRH3ALDH1A1MEN1KMT2A | |
| SCHEMBL4667342 | 0.86 | ACKR3 (0.43) | HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802307-B1 | PYRROLIDINE DERIVATIVES AS HISTAMINE RECEPTORS LIGANDS | GLAXO GROUP LTD (GB) | 2008-02-27 | — | — | EP | claimed |