Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.73 |
| ▸ | PRKCB | P05771 | 14/20 | 0.73 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.69 |
| ▸ | CDK1 | P06493 | 3/20 | 0.69 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.69 |
| ▸ | CDK2 | P24941 | 3/20 | 0.69 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.69 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.69 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.69 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | PRKCG | P05129 | 6/20 | 0.60 |
| ▸ | PRKCA | P17252 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768783 | 0.91 | GSK3B (0.67) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL4762233 | 0.87 | GSK3B (0.86) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL4338729 | 0.85 | GSK3B (1.00) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL13204222 | 0.82 | GSK3B (1.00) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL2974578 | 0.80 | GSK3B (0.80) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL2982963 | 0.79 | GSK3B (0.78) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL2987297 | 0.75 | GSK3B (1.00) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL2982584 | 0.74 | GSK3B (1.00) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL4337844 | 0.74 | GSK3B (1.00) | GSK3BPRKCBCCNB2CDK1CCNB1 | |
| SCHEMBL13204339 | 0.73 | GSK3B (1.00) | GSK3BPRKCBCCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1900738-A2 | Substituted pyrroline kinase inhibitors | Janssen Pharmaceutica, N.V. (BE) | 2008-03-19 | — | — | EP | disclosed |