Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 13/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GALK1 | P51570 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774396 | 1.00 | TRPV1 (0.49) | TRPV1KDM4EMAPTALDH1A1KMT2A | |
| SCHEMBL4778224 | 0.90 | TRPV1 (0.53) | TRPV1KDM4EMAPTGALK1ATM | |
| SCHEMBL4778931 | 0.90 | TRPV1 (0.55) | TRPV1KDM4EMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4779225 | 0.88 | TRPV1 (0.61) | TRPV1 | |
| SCHEMBL4777147 | 0.87 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL4779260 | 0.85 | TRPV1 (0.52) | TRPV1CYP3A4 | |
| SCHEMBL4779427 | 0.83 | EPHX2 (0.51) | TRPV1KDM4EMAPTALDH1A1KMT2A | |
| SCHEMBL4780425 | 0.82 | TRPV1 (0.49) | TRPV1CYP3A4CCNE1CDK2CDK5 | |
| SCHEMBL4780244 | 0.82 | TRPV1 (0.50) | TRPV1CCNE1CDK2CDK5 | |
| SCHEMBL4778989 | 0.82 | KDM4E (0.49) | TRPV1KDM4EMAPTALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | claimed |
| WO-2008010061-A2 | 3-AZABICYCLO [3.1.0] HEXANE VANILLOID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION | GLENMARK PHARMACEUTICALS S.A. (US) | 2008-01-24 | — | — | WO | disclosed |