Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 6/20 | 0.49 |
| ▸ | TYRO3 | Q06418 | 8/20 | 0.48 |
| ▸ | MERTK | Q12866 | 8/20 | 0.48 |
| ▸ | AXL | P30530 | 6/20 | 0.48 |
| ▸ | FLT3 | P36888 | 5/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 2/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793362 | 0.93 | CSF1R (0.55) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3293647 | 0.92 | CSF1R (0.58) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3290848 | 0.91 | CSF1R (0.52) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL4775380 | 0.91 | CSF1R (0.55) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3290575 | 0.89 | CSF1R (0.49) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3293840 | 0.89 | CSF1R (0.64) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3290610 | 0.87 | CSF1R (0.63) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3290835 | 0.86 | CSF1R (0.54) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3290704 | 0.85 | CSF1R (0.59) | CSF1RTYRO3MERTKAXLFLT3 | |
| SCHEMBL3291008 | 0.84 | CSF1R (0.65) | CSF1RTYRO3MERTKAXLFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | claimed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | claimed |
| EP-1945637-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007033137-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |