Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4779334 | 0.77 | — | — | |
| SCHEMBL8217044 | 0.68 | NAMPT (0.37) | NAMPTHDAC1PDE2A | |
| SCHEMBL4779331 | 0.67 | HDAC8 (0.39) | NAMPTHDAC1 | |
| SCHEMBL4910552 | 0.67 | HDAC8 (0.39) | NAMPTHDAC1 | |
| SCHEMBL22098106 | 0.65 | NOTUM (0.47) | NAMPTHDAC1PDE2A | |
| SCHEMBL17106486 | 0.62 | NAMPT (0.46) | NAMPTHDAC1PDE2A | |
| SCHEMBL25639012 | 0.62 | NAMPT (0.48) | NAMPTHDAC1PDE2A | |
| SCHEMBL30838602 | 0.62 | HDAC1 (0.47) | NAMPTHDAC1PDE2A | |
| SCHEMBL1721216 | 0.60 | HDAC1 (0.46) | NAMPTHDAC1PDE2A | |
| SCHEMBL29379757 | 0.60 | HDAC1 (0.46) | NAMPTHDAC1PDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1996550-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | Novartis AG (CH) | 2008-12-03 | — | — | EP | disclosed |
| WO-2007038459-A2 | CARBOXYAMINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF HDAC DEPENDENT DISEASES | NOVARTIS AG (CH) | 2007-04-05 | — | — | WO | disclosed |