Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 9/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5116424 | 0.91 | PIK3CA (0.39) | PDE4B | |
| SCHEMBL4779577 | 0.85 | PDE4B (0.47) | ADORA3PDE4BLMNAMEN1GMNN | |
| SCHEMBL4774090 | 0.81 | PDE1C (0.37) | PDE4BLMNAMEN1ALDH1A1MAPT | |
| SCHEMBL4778516 | 0.81 | RARB (0.37) | ADORA3PDE4BSMN1; SMN2 | |
| SCHEMBL4778518 | 0.81 | RARB (0.37) | ADORA3PDE4BSMN1; SMN2 | |
| SCHEMBL4774023 | 0.80 | MAPT (0.56) | ADORA3PDE4BLMNAMEN1GMNN | |
| SCHEMBL4772372 | 0.75 | MAPT (0.47) | ADORA3PDE4BLMNAMEN1GMNN | |
| SCHEMBL4776614 | 0.74 | KDM4E (0.46) | ADORA3PDE4BLMNAMEN1GMNN | |
| SCHEMBL4778834 | 0.73 | MAPT (0.48) | ADORA3PDE4BLMNAMEN1GMNN | |
| SCHEMBL4776279 | 0.72 | PIK3CA (0.38) | PDE4BUSP2ALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1763528-B1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC (JP) | 2008-11-26 | — | — | EP | disclosed |
| EP-1763528-A1 | PYRAZOLOPYRIDINE DERIVATIVES | Astellas Pharma Inc. (JP) | 2007-03-21 | — | — | EP | disclosed |
| WO-2006004188-A1 | PYRAZOLOPYRIDINE DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2006-01-12 | — | — | WO | disclosed |