Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.78 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | JAK3 | P52333 | 3/20 | 0.51 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.51 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.51 |
| ▸ | GRK6 | P43250 | 7/20 | 0.49 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075967 | 1.00 | NTRK1 (0.78) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4066038 | 0.87 | NTRK1 (1.00) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4077514 | 0.86 | NTRK1 (0.79) | NTRK1JAK2JAK3 | |
| SCHEMBL4900453 | 0.86 | NTRK1 (0.79) | NTRK1JAK2JAK3 | |
| SCHEMBL3338612 | 0.82 | NTRK1 (0.69) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL22535807 | 0.78 | NTRK1 (0.60) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL22535467 | 0.77 | NTRK1 (0.61) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL22535416 | 0.76 | NTRK1 (0.69) | NTRK1JAK2JAK3LIMK1LIMK2 | |
| SCHEMBL4073788 | 0.74 | NTRK1 (1.00) | NTRK1JAK2JAK3 | |
| SCHEMBL14041534 | 0.74 | JAK2 (0.74) | NTRK1JAK2JAK3LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1877057-A1 | USE OF PYRAZOLYL-PYRIMIDINE DERIVATIVES IN THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006115452-A1 | USE OF PYRAZOLYL-PYRIMIDINE DERIVATIVES IN THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2006-11-02 | — | — | WO | disclosed |