Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4667621 | 0.92 | SLC6A2 (0.55) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4668125 | 0.79 | SLC6A4 (0.54) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4781103 | 0.75 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4776529 | 0.75 | SLC6A4 (0.52) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4665146 | 0.75 | SLC6A2 (0.59) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4667826 | 0.75 | SLC6A2 (0.57) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL5823064 | 0.75 | TACR1 (0.48) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4669138 | 0.74 | SLC6A2 (0.46) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4726503 | 0.74 | SLC6A2 (0.50) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 | |
| SCHEMBL4634790 | 0.72 | SLC6A2 (0.69) | SLC6A4SLC6A2SLC6A3KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638933-B1 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALINE RE-UPTAKE INHIBITORS | PFIZER LTD (GB) | 2008-06-11 | — | — | EP | claimed |