Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 6/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
| ▸ | CTSC | P53634 | 1/20 | 0.33 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | LIPC | P11150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3216298 | 0.92 | PTPN1 (0.52) | PTPN1PRMT5WDR77NAMPTIDH1 | |
| SCHEMBL3226584 | 0.85 | PTPN1 (0.52) | PTPN1PRMT5WDR77NAMPTIDH1 | |
| SCHEMBL3214685 | 0.83 | PTPN1 (0.50) | PTPN1PRMT5WDR77NAMPTPTPN2 | |
| SCHEMBL3201397 | 0.80 | PTPN1 (0.53) | PTPN1PRMT5WDR77NAMPTCTSK | |
| SCHEMBL2937480 | 0.76 | PTPN1 (0.50) | PTPN1PRMT5WDR77NAMPTPTPN2 | |
| SCHEMBL31328076 | 0.76 | PTPN1 (0.50) | PTPN1PRMT5WDR77NAMPTPTPN2 | |
| SCHEMBL4782763 | 0.74 | PTPN1 (0.46) | PTPN1PTPN2 | |
| SCHEMBL12056201 | 0.74 | PTPN1 (0.74) | PTPN1PTPN2 | |
| SCHEMBL27737851 | 0.73 | PRMT5 (0.39) | PRMT5WDR77NAMPTIDH1CTSK | |
| SCHEMBL3213594 | 0.72 | PTPN1 (0.53) | PTPN1PRMT5WDR77NAMPTCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008067527-A1 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE FOR THE TREATMENT OF MUSCLE ATROPHY AND RELATED DISORDERS | NOVARTIS AG (CH) | 2008-06-05 | — | — | WO | disclosed |