Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 4/20 | 0.52 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.50 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | ATR | Q13535 | 7/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.46 |
| ▸ | ATRIP | Q8WXE1 | 3/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521616 | 0.96 | PIK3CB (0.53) | PDCD1CD274PIK3CBMOKPIK3CA | |
| SCHEMBL4728818 | 0.89 | PIK3CB (0.60) | PIK3CBMOKPIK3CAPIK3CDPIK3CG | |
| SCHEMBL4523237 | 0.84 | PIK3CD (0.45) | PDCD1CD274PIK3CBMOKPIK3CA | |
| SCHEMBL3993035 | 0.82 | PIK3CB (0.56) | PDCD1CD274PIK3CBPIK3CAPIK3CD | |
| SCHEMBL4532379 | 0.82 | PIK3CB (0.61) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL4838406 | 0.81 | PIK3CB (0.69) | PDCD1CD274PIK3CBPIK3CAPIK3CD | |
| SCHEMBL4730534 | 0.81 | PIK3CB (0.69) | PDCD1CD274PIK3CBPIK3CAPIK3CD | |
| SCHEMBL4590287 | 0.81 | PIK3CB (0.52) | PDCD1CD274PIK3CBPIK3CAPIK3CD | |
| SCHEMBL4573091 | 0.81 | PIK3CB (0.66) | PDCD1CD274PIK3CBPIK3CAPIK3CD | |
| SCHEMBL4525405 | 0.80 | PIK3CB (0.58) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008032027-A1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-20 | — | — | WO | disclosed |