SCHEMBL4781932 — predicted protein targets

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	PLK1	P53350	12/20	0.52

▸	PLK3	Q9H4B4	9/20	0.52

▸	PLK2	Q9NYY3	8/20	0.43

▸	BRD4	O60885	4/20	0.43

▸	MAPK7	Q13164	2/20	0.43

▸	PARP1	P09874	2/20	0.42

▸	PIP4K2A	P48426	1/20	0.42

▸	PIP4K2B	P78356	1/20	0.42

▸	MARK3	P27448	2/20	0.40

▸	MARK4	Q96L34	1/20	0.39

▸	TAF1	P21675	1/20	0.39

▸	DYRK1A	Q13627	1/20	0.39

▸	RPS6KA3	P51812	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4798215	0.89	PLK1 (0.55)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4782678	0.88	PLK1 (0.57)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4731693	0.88	PLK1 (0.54)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4730395	0.88	PLK1 (0.54)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4779460	0.88	PLK1 (0.54)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4782049	0.88	PLK1 (0.55)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4784197	0.87	PLK1 (0.56)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4780462	0.87	PLK1 (0.53)	PLK1PLK3PLK2BRD4MAPK7
SCHEMBL4784694	0.87	PLK1 (0.59)	PLK1PLK3
SCHEMBL4782734	0.86	PLK1 (0.52)	PLK1PLK3PLK2BRD4MAPK7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008040951-A1	COMPOUNDS	ASTRAZENECA AB (SE)	2008-04-10	—	—	WO	disclosed