Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 0.58 |
| ▸ | LIMK1 | P53667 | 6/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.46 |
| ▸ | PRKACA | P17612 | 5/20 | 0.46 |
| ▸ | PRKACG | P22612 | 5/20 | 0.46 |
| ▸ | PRKACB | P22694 | 5/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4725763 | 0.83 | AKT1 (0.64) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4726055 | 0.81 | AKT1 (0.60) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4796846 | 0.80 | AKT1 (0.63) | AKT1 | |
| SCHEMBL4778662 | 0.79 | AKT1 (0.62) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4726082 | 0.78 | AKT1 (0.70) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4727205 | 0.78 | AKT1 (0.73) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4918784 | 0.75 | AKT1 (0.73) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4778792 | 0.74 | AKT1 (0.64) | AKT1LIMK2 | |
| SCHEMBL4776438 | 0.74 | AKT1 (0.64) | AKT1LIMK1ROCK2PRKACAPRKACG | |
| SCHEMBL4776369 | 0.73 | AKT1 (0.61) | AKT1LIMK1ROCK2PRKACAPRKACG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008012635-A2 | AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2008-01-31 | — | — | WO | disclosed |