Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 15/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2749235 | 0.86 | MAPT (0.49) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL8147325 | 0.85 | MAPT (0.46) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL191477 | 0.83 | MAPT (0.48) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL8144938 | 0.82 | MAPT (0.48) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL31411153 | 0.81 | LRRK2 (0.55) | MEN1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL7093493 | 0.79 | MAPT (0.39) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL12744372 | 0.79 | MAPT (0.46) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL13914461 | 0.78 | PDE10A (0.43) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL13914462 | 0.78 | MAPT (0.47) | MEN1KMT2ASMN1; SMN2PDE10AMAPT | |
| SCHEMBL1457261 | 0.78 | MAPT (0.40) | MEN1KMT2ASMN1; SMN2PDE10AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008030511-A2 | SUBSTITUTED 3,4,6,7-TETRAHYDRO-5H, 1,2A,4A,8-TETRAAZACYCLOPENTA[CD]PHENALENES | COLEY PHARMACEUTICIAL GROUP, INC. (US) | 2008-03-13 | — | — | WO | disclosed |