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SCHEMBL4782285

SCHEMBL4782285

O=C(O)/C=C/c1ccc2c(c1)CC(NS(=O)(=O)c1ccccc1C(F)(F)F)C2

nearest known ligand 0.51

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ NR1H2 P55055 1/20 0.51
▸ SFRP1 Q8N474 15/20 0.45
▸ WNT3 P56703 3/20 0.45
▸ KDM4E B2RXH2 2/20 0.41
▸ POLB P06746 1/20 0.41
▸ GAA P10253 1/20 0.41
▸ HTT P42858 1/20 0.41
▸ TDP1 Q9NUW8 1/20 0.41
▸ L3MBTL1 Q9Y468 1/20 0.41
▸ APOB P04114 2/20 0.41
▸ MTTP P55157 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4782289 1.00 NR1H2 (0.51) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4782869 0.91 KDM4E (0.44) NR1H2KDM4EPOLBGAAHTT
SCHEMBL4782858 0.91 KDM4E (0.44) NR1H2KDM4EPOLBGAAHTT
SCHEMBL4783220 0.89 NR1H2 (0.46) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4783212 0.89 NR1H2 (0.46) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4782255 0.89 NR1H2 (0.46) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4782252 0.89 NR1H2 (0.46) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4782875 0.87 NR1H2 (0.42) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4780660 0.86 NR1H2 (0.43) NR1H2SFRP1WNT3KDM4EPOLB
SCHEMBL4780662 0.86 NR1H2 (0.43) NR1H2SFRP1WNT3KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061006-A1 SUBSTITUTED INDAN-2-YL, TETRAHYDRONAPHTHALEN-2-YL, OR DIHYDR0-2H-CHR0MEN-3-YL ARYLSULFONAMIDES AND METHODS OF THEIR USE WYETH (US) 2008-05-22 — — WO disclosed